Home List your patent My account Help Support us
Heparanase Inhibitors and Use Thereof
[Category : - HEALTH]
[Viewed 329 times]
The invention relates to functionalized quinazoline compounds, pharmaceutical compositions comprising such compounds, and the use of such compounds as heparanase inhibitors for the treatment of diseases or conditions related to heparanse activity.
The innate immune system and macrophages in particular have been identified as key players contributing to inflammatory disease as well as cytokine storm syndromes (CSS) and hyperinflammation
Our target: Heparanase, an enzyme with a multifaceted role in the inflammatory response; Particularly, heparanase plays a key role in macrophage activation triggering the release of a whole range of pro-inflammatory cytokines
Our approach: Targeting heparanase to reduce macrophage activation and subsequently reduce overall cytokine release, instead of inhibiting only one cytokine or pathway, could potentially provide a groundbreaking approach to treat various inflammatory conditions and CSS independent of the underlying trigger
Clinical opportunities: These range from inflammatory disease where single cytokines are currently targeted with biologics (eg anti-TNF, anti-IL6) through to cytokine storms associated with rare disorders such as Haemophagocytic lymphohistiocytosis (HLH), Macrophage Activation Syndrome (MAS), Cytokine Release Syndrome (CRS) or cytokine storm associated uncontrolled response to virus (eg COVID-19)
Market opportunities: While high unmet need, low number of competitors, and potential orphan/breakthrough designation make HLH & CRS attractive markets for initial indications, there is the possibility to penetrate much broader markets of severe inflammatory diseases, potentially competing with current blockbuster therapies
Financial information
Note that there are two patent families with patents granted in:
WO2018107200A1 - CN, US, JP, AU, IL, MX
WO2018107201A1 - AU, IL
These patents have been assigned back to the Australian National University by Beta Therapeutics. We are seeking a new home for the patents, which can be a like minded university or a company wanting to bolster an existing position. We also have a significant amount of research data on several compounds for testing.
Patent publications:
US 11718609
CN 110291073
Asking price:
Make an offer
Make an offer
Great invention[ Home | List a patent | Manage your account | F.A.Q.|Terms of use | Contact us]
Copyright PatentAuction.com 2004-2017
Page created at 2025-04-03 10:52:05, Patent Auction Time.