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COMPOSITIONS AND METHODS TO PREVENT AND TREAT BIOFILMS

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Compositions and methods to treat biofilms are disclosed based on the discovery of the role of the disaccharide trehalose in microbial biofilm development. In various embodiments to treat body-borne biofilms systemically and locally, the method includes administering trehalase, the enzyme which degrades trehalose, in combination with other saccharidases for an exposition time sufficient to adequately degrade the biofilm gel matrix at the site of the biofilm. The method also includes administering a combination of other enzymes such as proteolytic, fibrinolytic, and lipolytic enzymes to break down proteins and lipids present in the biofilm, and administering antimicrobials for the specific type(s) of infectious pathogen(s) underlying the biofilm. Additionally, methods are disclosed to address degradation of biofilms on medical device surfaces and biofilms present in industrial settings.

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There are 3 additional patents related to this listing.

1 - Active European Patent #2717926 B 1, issued May 24, 2017 (with priority date of June 1, 2012) has broad Key Claims for IP utilization in the Medical field (Pharmaceutical / Medical Devices / Catheters areas) and in the Industrial field (HV/AC systems and the oil-pipelines). The Patent is validated in eight European Countries: Belgium, Denmark, France, Germany, The Netherlands, Sweden, Switzerland and the United Kingdom.

2 - The US PTO Patent No 10,420,822 B 2 “Continuation-in-Part -1” (CIP-1), issued September 24, 2019 (with priority date of June 13, 2011) has specific Claims in the Medical field (Pharmaceutical / Medical devices / Catheters areas).

3 – The US PTO Patent Application # 16546424 “Continuation-in-Part-1 – Continuation-1” (CIP-1-CON-1), filed with the US PTO August 21, 2019 has specific Claims in the Medical field (Pharmaceutical and Consumer Health products areas), including manufacturing the advanced dermatological products for prevention and treatment of biofilm-based skin and soft tissue infections and wound care.

4 – The US PTO Patent Application # 16/686,437 “Continuation-in-Part-2” (CIP-2), filed with the US PTO November 18, 2019 has Claims in the Industrial field (including Microbiologically Influenced Corrosion, i.e. Biocorrosion areas).

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US 10420822

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