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[Category : - HEALTH]
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BACKGROUND: Researchers of the Medical University of Vienna and the University of Vienna have identified highly active synthetic chalcones derived from the chalcone scaffold. These cytotoxic compounds were found and developed by modifying the chalcone lead structure concurrent with in vitro tests to evaluate their cytotoxic potential in different cancer cell lines. Compounds were thoroughly tested regarding their efficacy in inhibiting proliferation and viability in cancer cell lines of the hematopoietic system (eg. CLL).
From these tests, one representative emerged, which inhibits proliferation of CLL cells in vitro at very low concentrations and simultaneously displays less effect on healthy donor cell growth.
The combination of the new chalcone compound with the targeting agents, Idelalisib and Ibrutinib, which are novel compounds in the treatment of hematological malignancies, displayed higher cytotoxicity on CLL cells than Idelalisib and Ibrutinib alone.

Potential Applications
-Treatment of lymphomas
-Treatment of solid tumors

Patents granted
EP15770817 (B)
US10280156 (B2)

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