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MODIFIED SYNTHETIC PEPTIDES DERIVED FROM HONEY IN CANCER CONTROL

[Category : - HEALTH]
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Many trials were done to get more potent and stable anti-cancer peptides. Synthetic peptides derived from honey were modified to obtain promising peptides in cancer control. We modified the first two amino acids of the N-terminus and the last three amino acids of the C-terminus to be in the D-form instead of the L-form plus we added a NH2-group to the N-terminus and a COOH-group to the C-terminus. We found that the following peptides with the sequences from N-terminus to C-terminus have more potent anti-cancer effects plus more stability in human serum than the non-modified peptides of patent W0/2014/040605. Seven peptides similar to peptide F of patent W0/2014/040605 were postulated of more or less similar actions for further assessment experiments and maybe modification.

Patent publications:

WO 2017182044

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dodo (Egypt)

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