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CHIMERIC IMMUNOGLOBULIN PREPARATION

[Category : - HEALTH- Organic Chemistry]
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FULL NAME: CHIMERIC IMMUNOGLOBULIN PREPARATION WITH SPECIFIC ANTIVIRAL OR ANTIBACTERIAL EFFECT

FIELD: medicine.

SUBSTANCE: The invention relates to biotechnology and immunology. Proposed is a chimeric immunoglobulin preparation containing immunoelectrophoretically pure chimeric secretory immunoglobulin А (S-IgA), isolated from the milk serum and/or colostral serum of immunized cows, in which the bovine secretory component is substituted by a human donor component or recombinant component. The base preparation (substance) contains 6-12% chimeric S-IgA, has a pH value of 4-8 and an anticomplementary activity of at least 10 mg of protein, not activating 2 CH50, protects in >70% against infection (in the event of infection of the macroorganism in doses of 10 ID50), is not reactogenic in the case of intravenous administration, and can contain stabilizing additives in a total concentration of not more than 4%. Technical result: reduced immunogenicity and reactogenicity, and a broader range of therapeutic effectiveness.

Patent publications:

WO 2017010911

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mbs.guschin (Russian Federation)

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