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MONOCLONAL ANTIBODY MIRACULUM

[Category : - HEALTH]
[Viewed 1487 times]

Blood typing is one of the most fundamental diagnostic tests performed routinely in blood donors and recipients and also in pregnant women. Safe transfusions and transplants became possible after discovery of molecular differences between blood groups, which was followed by development of suitable diagnostic reagents. The main component of such reagents are monoclonal antibodies. Monoclonal antibody selectively interacts with a specific antigen on the surface of red blood cells and can be used for antigen detection.rnDetermination of blood group typically is carried out using hemagglutination. Antibodies used worldwide for the diagnostics of blood groups belong to IgM class. Although antibodies of IgM class efficiently induce agglutination, they are unstable, tend to aggregate and quickly lose their agglutinating activity. Antibodies of IgG class, which are very stable and resistant to temperature changes, including freezing, generally do not agglutinate red blood cells.rnThe subject of the offer is a new IgG antibody suitable for specific agglutination of erythrocytes, particularly for blood typing. The unique IgG3 antibody Miraculum developed by researchers at the Jagiellonian University agglutinates red blood cells expressing antigen B. Miraculum may be a valuable, high-quality, next generation blood typing reagent with extended shelf life. Miraculum does not lose its property after freezing. Its production is very efficient and can be more profitable compared to currently used IgM-class antibody.rnrnA comparison of Miraculum with IgM antibodies, which are currently used in serological diagnostics, revealed that:rn IgG3 antibodies are extremely stable – they retain full activity for at least five days at 42°C, while IgM antibodies begin to lose their functionality after 24 h;rn molar efficiency of production of IgG3 is more than fifteen times better than IgM antibodies;rn IgG3 antibodies can be easily purified using standard chromatographic techniques;rn IgG3 can be stored in a frozen state, which is not possible in the case of IgM antibodies.rnThe subject of the offer is also a new method of conversion of any non-agglutinating monoclonal antibody that recognizes an antigen on the surface of human erythrocytes into agglutinating molecule. The conversion is possible due to the rearrangement of a genetic sequence coding for the non-agglutinating antibody. The antibodies obtained in this way can be much more useful than IgM antibodies, which are currently used in agglutination assays.rnThe offered monoclonal antibody Miraculum as well as the method for preparing monoclonal antibodies able to agglutinate erythrocytes are patent pending. Further research and development of the invention are continued at the Faculty of Biochemistry, Biophysics and Biotechnology and Malopolska Centre of Biotechnology of the Jagiellonian University. Currently, the Centre for Innovation, Technology Transfer and University Development (CITTRU) is looking for entities interested in commercial application of the invention.rn

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