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Injectible Bodily Prosthetics

[Category : - HEALTH]
[Viewed 777 times]

The present invention provides novel block copolymers as structural supplements for injectible bodily prosthetics employed in medical or cosmetic procedures. The invention also includes the use of such block copolymers as nucleus pulposus replacement materials for the treatment of degenerative disc disorders and spinal injuries. The copolymers are constructed by polymerization of a tertiary amine methacrylate with either a (poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) polymer, such as the commercially available Pluronic(R) polymers, or a poly(ethylene glycol) methyl ether polymer.


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BENEFITS
• Thermo-reversible: the injectable material is an aqueous solution at room temperatures (or
lower) and will instantaneously form gels at body temperatures (37°C).
• Biocompatible: non-cytotoxic towards fibroblast cells.
• Improved mechanical properties, such as stiffness, compared to other thermo reversible gels.
• pH sensitive: can macroscopically self assemble based on pH
• Easily chemically cross-linked via functionalized side chains

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